HAE is a rare, genetic disorder estimated to affect about 1 in 50,000 people worldwide. The availability of TAKHZYRO to help prevent HAE attacks represents significant progress for those living with this chronic condition.” Until now, no modern therapies have been available to HAE patients in the country, and people with HAE rely on anabolic androgens and tranexamic acid for prophylaxis, and fresh frozen plasma for emergencies. “HAE is a severe, potentially fatal genetic condition that causes unpredictable, painful, and debilitating swelling attacks. “The approval of TAKHZYRO is exciting news for the HAE community in China, ” said Fiona Wardman, the Chief Regional Patient Advocate at Hereditary Angioedema International. 1 TAKHZYRO is a fully human monoclonal antibody (mAb) that inhibits the activity of plasma kallikrein, an enzyme which is uncontrolled in people with HAE, to help prevent HAE attacks. Retrieved May 7, 2015.Shanghai, CHINA, and Osaka, JAPAN, Decem– Takeda Pharmaceutical Company Limited ( TSE:4502/NYSE:TAK) (“Takeda”) today announced that China’s National Medical Products Administration (NMPA) has approved TAKHZYRO ® (lanadelumab) subcutaneous injection for prophylaxis to prevent attacks of hereditary angioedema (HAE) in patients 12 years and older. Recording Industry Association of America.
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Track listing Ĭredits adapted from the album's liner notes. The album became a three-time platinum certified album by the Recording Industry Association of America (RIAA). At Metacritic, which assigns a normalized rating out of 100 to reviews from mainstream critics, the album has received an average score of 56, based on 5 reviews. Initial critical response to Rule 3:36 was average. Rule 3:36 sold 276,000 during its first week. The album still contains explicit material, and was made in a clean version which only removes profanity and drug/violent lyrics are left in, although some profanity like the words "hoes" and "ass" are also left in. The disc is still mostly radio-friendly pop-themed music unlike his later albums, which contain disses of a more dark tone. The song received average airplay, and is also on the soundtrack to The Fast and the Furious (where it is titled "Furious"). Rule 3:36 contains the song titled "Fuck You", which is titled "Furious" as a clean version for radio play.
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The most successful single, " Put It on Me" featuring Vita, peaking at number 8 on the US Billboard Hot 100, becoming his first top-ten single on that chart as a lead artist, and scored his first nomination for Best Rap Performance by a Duo or Group at the 44th Grammy Awards. Rule 3:36 went on to be a certified triple platinum by the Recording Industry Association of America (RIAA), producing four singles all of which had achieved varying degrees of chart success. The album marked a significant change in Ja Rule's musical style, shifting from the hardcore hip hop, which made him known for with his first album, to a more radio-friendly pop rap oriented sound to greater success, debuting atop of the US Billboard 200 with 276,000 copies sold. The album features guest appearances from Christina Milian, Lil' Mo, Shade Sheist and Jayo Felony, with producers Irv Gotti, Ty Fyffe, Lil Rob and Damizza contributing to the album. It was released on October 10, 2000, by Murder Inc. Rule 3:36 is the second studio album by American rapper Ja Rule.